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Article

Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.

Human molecular genetics - 1 Feb 2018

Tönjes Anke, Scholz Markus, Krüger Jacqueline, Krause Kerstin, Schleinitz Dorit, Kirsten Holger, Gebhardt Claudia, Marzi Carola, Grallert Harald, Ladenvall Claes, Heyne Henrike, Laurila Esa, Kriebel Jennifer, Meisinger Christa, Rathmann Wolfgang, Gieger Christian, Groop Leif, Prokopenko Inga, Isomaa Bo, Beutner Frank, Kratzsch Jürgen, Fischer-Rosinsky Antje, Pfeiffer Andreas, Krohn Knut, Spranger Joachim, Thiery Joachim, Blüher Matthias, Stumvoll Michael, Kovacs Peter

Abstract excerpt

Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present study aimed at identification of genetic factors determining progranulin concentrations. We conducted a genome-wide association meta-analysis for serum progranulin in three independent cohorts from Europe: Sorbs (N = 848) and KORA (N = 1628) from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29186428
DOI: 10.1093/hmg/ddx413

Genes

PSRC1
CDH23
CELSR2
GRN
MYBPHL
PSAP
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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