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Article

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.

Breast cancer research and treatment - 1 Jul 2010

Han Chan H, Lu Jiachun, Wei Qingyi, Bondy Melissa L, Brewster Abenaa M, Yu Tse-Kuan, Buchholz Thomas A, Arun Banu K, Wang Li-E

Abstract excerpt

PIN1, an isomerase that causes conformational changes in proteins, plays an important role in mammary epithelial cell growth both physiologically and pathologically. Thus, genetic variants in the PIN1 gene may alter protein function and cancer risk. We have previously demonstrated an association...

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Source

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Identifiers

PMID: 20033770
DOI: 10.1007/s10549-009-0682-9
PMCID: PMC2883663

Genes

PIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20033770-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.PMID 20033770Read ↗

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.Semantic proximity Read ↗

The Pin1 gene polymorphism and the susceptibility of oral squamous cell carcinoma in East China.Semantic proximity Read ↗

Pin1 promoter rs2233678 and rs2233679 polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations.Semantic proximity Read ↗

Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population.Semantic proximity Read ↗

The -842G/C polymorphisms of PIN1 contributes to cancer risk: a meta-analysis of 10 case-control studies.Semantic proximity Read ↗

Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis.Semantic proximity Read ↗

Association of rs2233678 and rs2233679 polymorphisms in the PIN1 gene with cancer risk: a meta-analysis.Semantic proximity Read ↗

Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma.Semantic proximity Read ↗

The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysis.Semantic proximity Read ↗

Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T > C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters.Semantic proximity Read ↗

Association of polymorphisms in PIN1 with progression and susceptibility in gastric cancer.Semantic proximity Read ↗

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