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Article

Do oxidatively modified proteins cause ALS?

Free radical biology & medicine - 15 Nov 2002

Valentine Joan Selverstone

Abstract excerpt

Over 90 individual mutations in SOD1 are known to cause familial amyotrophic lateral sclerosis (FALS). It is widely accepted that these mutations exert their toxic effects by a gain of function mechanism, but the nature of these toxic effects is as yet unknown. It has been proposed by several laboratories that reactions of FALS-mutant CuZnSOD are the source of elevated oxidative stress in CuZnSOD-linked FALS. It...

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Source

Identifiers

PMID: 12419463
DOI: 10.1016/s0891-5849(02)01080-8

Genes

SOD1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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