Article
Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
Molecular biology reports - 1 Jul 2020
Rahimi-Balaei Maryam, Jiao Xiaodan, Dalvand Azadeh, Shabanipour Shahin, Chung Seung H, Amiri Shayan, Kong Jimig, Marzban Hassan
Abstract excerpt
Microglia are the immune cells of the central nervous system involved in a variety of developmental processes, such as regulation of cell death and survival, spatial patterning, and contribute to the development of Purkinje cells (PCs) during migration. Microglia express immunoglobulin G Fc receptors (FcgRs). In this report, we describe microglial FcgR expression and its relation to abnormal PC migration in the...
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