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Article

The Impact of a Heterozygous SLCO1B3 Null Variant on the Indocyanine Green Retention Test.

Journal of pharmaceutical sciences - 1 Oct 2020

Anzai Kazuya, Tsuruya Kota, Morimachi Masashi, Arase Yoshitaka, Hirose Shunji, Hirabayashi Kenichi, Adachi Yukihiko, Kagawa Tatehiro

Abstract excerpt

Indocyanine green (ICG) retention test is widely used for preoperative evaluation of liver function. OATP1B3 (gene symbol: SLCO1B3) is the major transporter for hepatic ICG uptake. We previously demonstrated that the individuals with a homozygous SLCO1B3 null allele revealed markedly impaired ICG clearance. However, the effect of heterozygosity of this variant on ICG clearance remains unknown. We compared the...

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Identifiers

PMID: 32593714
DOI: 10.1016/j.xphs.2020.06.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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