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Article

miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling

26 Jun 2020

Abstract excerpt

Genomic instability (GI) predisposes cells to malignant transformation, however the molecular mechanisms that allow for the propagation of cells with a high degree of genomic instability remain unclear. Here we report that miR-181a is able to transform fallopian tube secretory epithelial cells through the inhibition of RB1 and stimulator-of-interferon-genes (STING) to propagate cells with a high degree of GI....

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PMID: 32591511
DOI: 10.1038/s41467-020-17030-w

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