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Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells

25 Jun 2020

Abstract excerpt

BACKGROUND: Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in PCSCs. This study aimed to investigate the efficacy of Notch signaling inhibition as an adjuvant to docetaxel (DOX) in PCSCs. METHODS: PCSCs derived from the PC-3 cell line were examined for...

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PMID: 32586404
DOI: 10.1186/s13287-020-01773-w

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