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Article

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.

Cancer research - 15 Feb 2014

Schroeder Anne, Herrmann Andreas, Cherryholmes Gregory, Kowolik Claudia, Buettner Ralf, Pal Sumanta, Yu Hua, Müller-Newen Gerhard, Jove Richard

Abstract excerpt

Androgen receptor (AR) signaling is important for prostate cancer progression. However, androgen-deprivation and/or AR targeting-based therapies often lead to resistance. Here, we demonstrate that loss of AR expression results in STAT3 activation in prostate cancer cells. AR downregulation further leads to development of prostate cancer stem-like cells (CSC), which requires STAT3. In human prostate tumor tissues,...

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Source

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Identifiers

PMID: 24177177
DOI: 10.1158/0008-5472.CAN-13-0594
PMCID: PMC4539262

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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