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Article

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway.

Cancer letters - 1 Aug 2016

Liu Naihua, Mei Liu, Fan Xueying, Tang Chao, Ji Xing, Hu Xinhua, Shi Wei, Qian Yu, Hussain Musaddique, Wu Junsong, Wang Chaojun, Lin Shaoqiang, Wu Ximei

Abstract excerpt

Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcription regulator protein-1 (TAZ), a core effector of Hippo pathway, are highly expressed in the...

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PMID: 27179930
DOI: 10.1016/j.canlet.2016.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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