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Article

Development of human prostate cancer stem cells involves epigenomic alteration and PI3K/AKT pathway activation

11 Jun 2020

Abstract excerpt

Abstract Background Human prostate cancer spheres endowed with stem cell properties have been obtained from androgen-dependent cell line LNCaP after exposure to an epigenomic modulator phenethyl isothiocynate (PEITC). Sphere cells can self-renew and grow with androgen, and also without androgen. Little is known about the signaling pathway and mechanism in the development of the stem cells in the spheres. Methods...

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PMID: 32537260
DOI: 10.1186/s40164-020-00168-0

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