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Article

Genetic risk factors for lumbar disc disease.

Clinical anatomy (New York, N.Y.) - 1 Jan 2021

Doraisamy Ravichandran, Ramaswami Karthikeyan, Shanmugam Jeevithan, Subramanian Rashmi, Sivashankaran Balasubramanian

Abstract excerpt

AIM AND BACKGROUND: Lumbar disc degeneration (LDD) is thought to be multifactorial in origin. Very recently the focus has shifted to the involvement of a family of candidate genes in the pathogenesis of LDD. There is particular emphasis on the vitamin D receptor gene (VDR gene). The VDR polymorphisms FOK1, TAQ1, and APO1 have been variably associated with LDD. OBJECTIVE: To evaluate the association between the...

Topics

Adult
Deoxyribonuclease I
Female
Genetic Predisposition to Disease
Genotype
Humans
Intervertebral Disc Degeneration
Intervertebral Disc Displacement
Lumbar Vertebrae
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Polymorphism, Genetic

Receptors, Calcitriol

Risk Factors

Young Adult

Source

Identifiers

PMID: 32583875
DOI: 10.1002/ca.23641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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