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Article

VDR and GC gene polymorphisms modulate the risk of lumbar disc degeneration in Iran.

Clinical neurology and neurosurgery - 1 Feb 2018

Mashayekhi Sohail, Saberi Alia, Salehi Zivar, Biazar Gelareh, Mehrdel Roghayeh

Abstract excerpt

OBJECTIVE: Lumbar disc degeneration (LDD) occurs commonly in humans. Vitamin D metabolic and signaling pathway plays a significant role in intervertebral disc degeneration. The aim of this study was to evaluate the influence of the genetic polymorphism in the two key genes of 1,25-(OH)2-D3 pathway, VDR (vitamin D receptor) and GC (group-specific component), in LDD development. PATIENTS AND METHODS: Two...

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Source

Identifiers

PMID: 29316495
DOI: 10.1016/j.clineuro.2017.12.024

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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