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VDR and GC gene polymorphisms modulate the risk of lumbar disc degeneration in Iran.

Clinical neurology and neurosurgery - 1 Feb 2018

Mashayekhi Sohail, Saberi Alia, Salehi Zivar, Biazar Gelareh, Mehrdel Roghayeh

Abstract excerpt

OBJECTIVE: Lumbar disc degeneration (LDD) occurs commonly in humans. Vitamin D metabolic and signaling pathway plays a significant role in intervertebral disc degeneration. The aim of this study was to evaluate the influence of the genetic polymorphism in the two key genes of 1,25-(OH)2-D3 pathway, VDR (vitamin D receptor) and GC (group-specific component), in LDD development. PATIENTS AND METHODS: Two...

Topics

Adult
Alleles
Female
Genetic Predisposition to Disease
Genetic Testing
Humans
Intervertebral Disc Degeneration
Iran
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Calcitriol

Risk

Vitamin D-Binding Protein

Young Adult

Source

Identifiers

PMID: 29316495
DOI: 10.1016/j.clineuro.2017.12.024

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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