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Article

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.

Nature communications - 23 Jun 2020

Avrutsky Maria I, Ortiz Crystal Colón, Johnson Kendra V, Potenski Anna M, Chen Claire W, Lawson Jacqueline M, White Alexandra J, Yuen Stephanie K, Morales Fatima N, Canepa Elisa, Snipas Scott, Salvesen Guy S, Jean Ying Y, Troy Carol M

Abstract excerpt

Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the blood-retina barrier, using a panel of interrelated ophthalmic in vivo imaging measures in a mouse model of retinal vein occlusion (RVO). Rapid nonapoptotic...

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Identifiers

PMID: 32576823
DOI: 10.1038/s41467-020-16902-5
PMCID: PMC7311551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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