Article
Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2020
Griffiths Jason I, Wallet Pierre, Pflieger Lance T, Stenehjem David, Liu Xuan, Cosgrove Patrick A, Leggett Neena A, McQuerry Jasmine A, Shrestha Gajendra, Rossetti Maura, Sunga Gemalene, Moos Philip J, Adler Frederick R, Chang Jeffrey T, Sharma Sunil, Bild Andrea H
Abstract excerpt
The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor immune activity prior to and early in cancer therapy is unclear. To address this question, we studied the population dynamics of tumor and immune cells, and immune phenotypic changes, using clinical tumor and immune cell measurements and single-cell genomic analyses. These samples were serially obtained from a cohort of...
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