Article
The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women.
Diabetes & metabolism - 1 Dec 2005
Oliveira C S V, Hauache O M, Vieira J G H, Maciel R M B, Sjöroos M, Canani L H, Velho G, Gross J L, Reis A F
Abstract excerpt
BACKGROUND: NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. In this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects. METHODS: A population/association study comprising 246 unrelated Type 1 diabetic and 275...
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