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Article

Variants in the FFAR1 gene are associated with beta cell function.

PloS one - 7 Nov 2007

Kalis Martins, Levéen Per, Lyssenko Valeriya, Almgren Peter, Groop Leif, Cilio Corrado M

Abstract excerpt

BACKGROUND: The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medium to long chain free fatty acids (FFAs), as well as by thiazolidinediones, resulting in elevated Ca(2+) concentrations and promotion of insulin secretion. These properties suggest that FFAR1 could be a mediator of lipotoxicity and a potential candidate gene for Type 2 diabetes (T2D). We therefore investigated...

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Source

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Identifiers

PMID: 17987108
DOI: 10.1371/journal.pone.0001090
PMCID: PMC2042513

Genes

FFAR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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