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Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

22 Jun 2020

Abstract excerpt

The bifunctional human enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) catalyzes two essential steps in the de novo purine biosynthesis pathway. PAICS is overexpressed in many cancers and could be a promising target for the development of cancer therapeutics. Here, using gene knockdowns and clonogenic survival and cell viability assays, we...

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PMID: 32571877
DOI: 10.1074/jbc.ra120.013695

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