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Article

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines

10 Aug 2018

Abstract excerpt

BACKGROUND: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesis. This study aimed to evaluate the role of PAICS in human breast cancer, which remains the most frequently diagnosed cancer and the leading cause of cancer-related death among women in less...

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PMID: 30097015
DOI: 10.1186/s40659-018-0172-9

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