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Article

Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer

22 Aug 2016

Abstract excerpt

BACKGROUND: Our goal was to investigate de novo purine biosynthetic gene PAICS expression and evaluate its role in prostate cancer progression. METHODS: Next-generation sequencing, qRTPCR and immunoblot analysis revealed an elevated expression of a de novo purine biosynthetic gene, Phosphoribosylaminoimidazole Carboxylase, Phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS) in a progressive manner...

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PMID: 27550065
DOI: 10.1002/pros.23243

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