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Article

Gene silencing of HIF-2α disrupts glioblastoma stem cell phenotype

1 Jan 2020

Abstract excerpt

AIM: Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), which drive malignancy and recurrence in glioblastoma multiforme. Hypoxic regions within the tumor microenvironment help maintain and promote the proliferation of CSCs. Here, we explored the effects of silencing hypoxia inducible factor-2α (HIF-2α) because of its specificity for CSCs within the hypoxic environment....

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PMID: 32566921
DOI: 10.20517/cdr.2019.96

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