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Promoter methylation of tumor suppressor genes induced by human papillomavirus in cervical cancer

14 May 2020

Abstract excerpt

Cervical cancer is the most fourth common cancer in women worldwide. The E6 and E7 high-risk human papillomavirus (HPV) types are the main cause of this cancer. Several studies have revealed that promoter methylation of tumor suppressor genes is induced by HPV E7. Recently, it was found that HPV16‑E7 and the DNA methyltransferase 1 complex could bind at the cyclin A1 (CCNA1) promoter, resulting in CCNA1 promoter...

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Share to Cancer-related gene regulation
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PMID: 32566025
DOI: 10.3892/ol.2020.11625

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