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Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer

9 Jun 2015

Abstract excerpt

Change in the host and/or human papillomavirus (HPV) DNA methylation profile is probably one of the main factors responsible for the malignant progression of cervical lesions to cancer. To investigate those changes we studied 173 cervical samples with different grades of cervical lesion, from normal to cervical cancer. The methylation status of nine cellular gene promoters, CCNA1, CDH1, C13ORF18, DAPK1, HIC1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26057381
DOI: 10.1371/journal.pone.0129452

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