Article

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

2024-02-07

Abstract excerpt

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly have started to emerge with the possibility to follow labeled sarcomere components. Here, we generated the mCherry knock-in at titin’s Z-disk to study skeletal muscle development and remodeling. We find...

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Literature Corpus work: f7000c65-e237-547f-b85a-8282d2b012a7
DOI: 10.1101/2024.02.01.578471

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