Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.

doi:10.1038/s41598-020-65869-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.

Scientific reports - 17 Jun 2020

Barat Ana, Smeets Dominiek, Moran Bruce, Zhang Wu, Cao Shu, Das Sudipto, Klinger Rut, Betge Johannes, Murphy Verena, Bacon Orna, Kay Elaine W, Van Grieken Nicole C T, Verheul Henk M W, Gaiser Timo, Schulte Nadine, Ebert Matthias P, Fender Bozena, Hennessy Bryan T, McNamara Deborah A, O'Connor Darran, Gallagher William M, Cremolini Chiara, Loupakis Fotios, Parikh Aparna, Mancao Christoph, Ylstra Bauke, Lambrechts Diether, Lenz Heinz-Josef, Byrne Annette T, Prehn Jochen H M

Abstract excerpt

Chemotherapy combined with the angiogenesis inhibitor bevacizumab (BVZ) is approved as a first-line treatment in metastatic colorectal cancer (mCRC). Limited clinical benefit underpins the need for improved understanding of resistance mechanisms and the elucidation of novel predictive biomarkers. We assessed germline single-nucleotide polymorphisms (SNPs) in 180 mCRC patients (Angiopredict [APD] cohort) treated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis Regulatory Proteins

Share to Bevacizumab

Share to Combined Modality Therapy

Share to Endoplasmic Reticulum

Share to Machine Learning

Share to NLR Proteins

Share to Progression-Free Survival

Source

Open in PubMed Open full text

Identifiers

PMID: 32555399
DOI: 10.1038/s41598-020-65869-2
PMCID: PMC7299973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.PMID 32555399Read ↗

An 8-Gene Bevacizumab Resistance Signature Predicts Prognosis and Reveals Immunosuppressive Microenvironment in Colorectal CancerSemantic proximity Read ↗

Biomarker Prediction and Immune Landscape of Angiogenesis in Inflammatory Bowel Disease: Insights from Bioinformatics and Machine Learning ApproachesSemantic proximity Read ↗

Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients.Semantic proximity Read ↗

VEGFA, FLT1, KDR and colorectal cancer: assessment of disease risk, tumor molecular phenotype, and survival.Semantic proximity Read ↗

Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy.Semantic proximity Read ↗

SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer.Semantic proximity Read ↗

Single-nucleotide polymorphisms in the vascular endothelial growth factor pathway and outcomes of patients treated with first-line cytotoxic chemotherapy combined with bevacizumab for advanced colorectal cancer.Semantic proximity Read ↗

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancerSemantic proximity Read ↗

Common variation in a long non-coding RNA gene modulates variation of circulating TGF-<i>β</i>2 levels in metastatic colorectal cancer patients (Alliance)Semantic proximity Read ↗

Biomarkers of Angiogenesis in Colorectal CancerSemantic proximity Read ↗

Genetic Variant of CXCR1 (rs2234671) Associates with Clinical Outcome in Perihilar CholangiocarcinomaSemantic proximity Read ↗

Common variation in a long non-coding RNA gene modulates variation of circulating TGF-β2 levels in metastatic colorectal cancer patients (Alliance).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.