Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

Abstract excerpt

Significance Cancer incidence increases exponentially in human midlife. Even though mutation accumulation in somatic tissues results in increased tumorigenesis, it is currently not understood how aging contributes to cancer. Telomeres, the ends of eukaryotic linear chromosomes, shorten with each cell division. Here, we show that telomere shortening contributes to cancer in a noncell autonomous manner. Using...

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• Share to Epigenetics and DNA Methylation
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