[A New Era of Colorectal Cancer Treatment Being Led by a Precise Analysis of Somatic Mutational Profiles Including RAS, BRAF Mutation and Microsatellite Instability Status].

Article

[A New Era of Colorectal Cancer Treatment Being Led by a Precise Analysis of Somatic Mutational Profiles Including RAS, BRAF Mutation and Microsatellite Instability Status].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 2020

Nagasaka Takeshi

Abstract excerpt

In Japan, clinically, a decade has passed since KRAS exon 2 hotspot mutations could be measured as a companion diagnostic agent of an anti-epidermal growth factor receptor antibody to treat unresectable advanced colorectal cancer. Till now, not only KRAS exon 2, but also KRAS exon 3, 4 and NRAS e...

Topics

Colorectal Neoplasms
Humans
Japan
Microsatellite Instability
Mutation
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)

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