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Metabolism and Toxicity of Emodin: Genome-Wide Association Studies Reveal Hepatocyte Nuclear Factor 4α Regulates UGT2B7 and Emodin Glucuronidation.

Chemical research in toxicology - 20 Jul 2020

Chen Yulian, Zhang Tao, Wu Lili, Huang Yilin, Mao Zhihao, Zhan Zhikun, Chen Weizhong, Dai Fahong, Cao Wenyu, Cao Yong, Liu Shuwen, Cai Zheng, Tang Lan

Abstract excerpt

Emodin is the main toxic component in Chinese medicinal herbs such as rhubarb. Our previous studies demonstrated that genetic polymorphisms of UDP-glucuronosyltransferase 2B7 (UGT2B7) had an effect on the glucuronidation and detoxification of emodin. This study aimed to reveal the transcriptional regulation mechanism of UGT2B7 on emodin glucuronidation and its effect on toxicity. Emodin glucuronic activity and...

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Identifiers

PMID: 32538071
DOI: 10.1021/acs.chemrestox.0c00047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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