Article
Gender Differences in the Hepatotoxicity and Toxicokinetics of Emodin: The Potential Mechanisms Mediated by UGT2B7 and MRP2.
Molecular pharmaceutics - 4 Sept 2018
Wu Lili, Han Weichao, Chen Yulian, Zhang Tao, Liu Junjin, Zhong Shilong, Liu Han, Han Congcong, Zhang Zhongyi, Liu Shuwen, Tang Lan
Abstract excerpt
Emodin is a main anthraquinone compound which exists in Chinese traditional medicines including Polygonum multiflorum and Rhubarb. It is documented to have obvious liver and kidney toxicity. This study aims to (a) estimate gender differences of the hepatotoxicity and toxicokinetics in rats after oral administration of emodin (60 and 150 mg/kg/d) for a consecutive 28 days and (b) clarify relative mechanisms caused...
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