Article
Polymorphism clustering of the 21.5 kb DPA-promoter-DPB region reveals novel extended full-length haplotypes.
HLA - 1 Sept 2020
Truong Linh, Matern Ben M, Groeneweg Mathijs, D'Orsogna Lloyd, Martinez Patricia, Tilanus Marcel G J, De Santis Dianne
Abstract excerpt
DPB1 and DPA1 genes share the same promoter region. Single-nucleotide polymorphisms (SNPs) within the regulatory regions of DP have been reported. This study hypothesizes that by including the SNPs in the promoter region of DP, extended haplotypes are defined, and promoter polymorphism is more extensive than what is currently reported. To identify the SNPs in the region of interest, the DP region spanning 21.5 kb...
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