Article
Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing.
Immunogenetics - 1 Nov 2005
Reinders Judith, Rozemuller Erik H, van Gent Rogier, Arts-Hilkes Yvonne H A, van den Tweel Jan G, Tilanus Marcel G J
Abstract excerpt
Most of the 119 human leukocyte antigen (HLA)-DPB1 alleles are defined by polymorphism in six hypervariable regions (HVRs) in exon 2 of the HLA-DPB1 gene. We investigated how DPB1 polymorphism is represented in the entire coding region. An RNA sequencing-based typing (SBT) approach was developed for the identification of HLA-DPB1 polymorphism from the 5' untranslated region (UTR) through the 3'-UTR. B-cell...
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