Article
Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens.
Scientific reports - 12 Jun 2020
Verma Nitin, Puri Ankit, Essuman Edward, Skelton Richard, Anantharaman Vivek, Zheng Hong, White Siera, Gunalan Karthigayan, Takeda Kazuyo, Bajpai Surabhi, Lepore Timothy J, Krause Peter J, Aravind L, Kumar Sanjai
Abstract excerpt
Babesia microti is an intraerythrocytic parasite and the primary causative agent of human babesiosis. It is transmitted by Ixodes ticks, transfusion of blood and blood products, organ donation, and perinatally. Despite its global public health impact, limited progress has been made to identify and characterize immunodominant B. microti antigens for diagnostic and vaccine use. Using genome-wide immunoscreening, we...
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