Article
Identification of Novel Antigenic Proteins in a ComplexAnaplasma marginaleOuter Membrane Immunogen by Mass Spectrometry and Genomic Mapping
18 Nov 2005
Abstract excerpt
Immunization with purified Anaplasma marginale outer membranes induces complete protection against infection that is associated with CD4+ T-lymphocyte-mediated gamma interferon secretion and immunoglobulin G2 (IgG2) antibody titers. However, knowledge of the composition of the outer membrane immunogen is limited. Recent sequencing and annotation of the A. marginale genome predicts at least 62 outer membrane...
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