Article
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Delle Monache Simona, Retta Saverio Francesco
Abstract excerpt
Cerebral cavernous malformation (CCM) proteins play critical roles for endothelial cell functions, including cytoskeletal remodeling, cell-cell interactions, cell polarity, tube formation, and angiogenesis. It has been shown that the mutation of even one of the CCM genes involved in CCMs can determine an alteration in the angiogenesis process, but the precise mechanism is yet to be clarified.Here using a model of...
Topics
- Cell Culture Techniques
- Cells, Cultured
- Endothelial Cells
- Endothelium, Vascular
- Hemangioma, Cavernous, Central Nervous System
- Humans
- KRIT1 Protein
- Microvessels
- Neovascularization, Pathologic
- Phenotype