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Article

Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Delle Monache Simona, Retta Saverio Francesco

Abstract excerpt

Cerebral cavernous malformation (CCM) proteins play critical roles for endothelial cell functions, including cytoskeletal remodeling, cell-cell interactions, cell polarity, tube formation, and angiogenesis. It has been shown that the mutation of even one of the CCM genes involved in CCMs can determine an alteration in the angiogenesis process, but the precise mechanism is yet to be clarified.Here using a model of...

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PMID: 32524565
DOI: 10.1007/978-1-0716-0640-7_26

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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