Article
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model.
Journal of visualized experiments : JoVE - 4 Sept 2017
Choi Jaesung P, Yang Xi, Foley Matthew, Wang Xian, Zheng Xiangjian
Abstract excerpt
Mutations in the CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation (CCM) in humans. Mouse models of CCM disease have been established by tamoxifen induced deletion of Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. An accurate and quantitative method to assess lesion...
Topics
- Animals
- Disease Models, Animal
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Mice
- Mutation
- X-Ray Microtomography