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Article

Pristane/Hypoxia (PriHx) Mouse as a Novel Model of Pulmonary Hypertension Reflecting Inflammation and Fibrosis.

Circulation journal : official journal of the Japanese Circulation Society - 25 Jun 2020

Mori Hiroyoshi, Ishibashi Tomohiko, Inagaki Tadakatsu, Okazawa Makoto, Masaki Takeshi, Asano Ryotaro, Manabe Yusuke, Ohta-Ogo Keiko, Narazaki Masashi, Ishibashi-Ueda Hatsue, Kumanogoh Atsushi, Nakaoka Yoshikazu

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension (PAH), particularly connective tissue disease-associated PAH (CTD-PAH), is a progressive disease and novel therapeutic agents based on the specific molecular pathogenesis are desired. In the pathogenesis of CTD-PAH, inflammation, immune cell abnormality, and fibrosis play important roles. However, the existing mouse pulmonary hypertension (PH) models do not reflect...

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Identifiers

PMID: 32522898
DOI: 10.1253/circj.CJ-19-1102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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