Article
Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension.
The European respiratory journal - 1 Apr 2020
Simpson Catherine E, Chen Jenny Y, Damico Rachel L, Hassoun Paul M, Martin Lisa J, Yang Jun, Nies Melanie, Griffiths Megan, Vaidya R Dhananjay, Brandal Stephanie, Pauciulo Michael W, Lutz Katie A, Coleman Anna W, Austin Eric D, Ivy Dunbar D, Nichols William C, Everett Allen D
Abstract excerpt
The pro-inflammatory cytokine interleukin (IL)-6 has been associated with outcomes in small pulmonary arterial hypertension (PAH) cohorts composed largely of patients with severe idiopathic PAH (IPAH). It is unclear whether IL-6 is a marker of critical illness or a mechanistic biomarker of pulmonary vascular remodelling. We hypothesised that IL-6 is produced by pulmonary vascular cells and sought to explore IL-6...
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