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Article

The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens.

Cell host & microbe - 8 Jul 2020

Kumar Aman, Russell Regan M, Pifer Reed, Menezes-Garcia Zelia, Cuesta Santiago, Narayanan Sanjeev, MacMillan John B, Sperandio Vanessa

Abstract excerpt

The gut-brain axis is crucial to microbial-host interactions. The neurotransmitter serotonin is primarily synthesized in the gastrointestinal (GI) tract, where it is secreted into the lumen and subsequently removed by the serotonin transporter, SERT. Here, we show that serotonin decreases virulence gene expression by enterohemorrhagic E. coli (EHEC) and Citrobacter rodentium, a murine model for EHEC. The...

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Source

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Identifiers

PMID: 32521224
DOI: 10.1016/j.chom.2020.05.004
PMCID: PMC7351610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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