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Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology

27 Nov 2024

Abstract excerpt

Bacteria in the gastrointestinal tract play a crucial role in intestinal motility, homeostasis, and dysfunction. Unraveling the mechanisms by which microbes impact the host poses many challenges due to the extensive array of metabolites produced or metabolized by bacteria in the gut. Here, we describe the engineering of a gut commensal bacterium, Escherichia coli Nissle 1917, to biosynthesize the human metabolite...

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PMID: 39601776
DOI: 10.1021/acssynbio.4c00453

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