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Article

Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host.

EBioMedicine - 1 Jul 2016

Knecht Leslie D, O'Connor Gregory, Mittal Rahul, Liu Xue Z, Daftarian Pirouz, Deo Sapna K, Daunert Sylvia

Abstract excerpt

Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacterial signaling molecule for pathogenic bacteria. Specifically, we found that serotonin acts as an interkingdom...

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Identifiers

PMID: 27333040
DOI: 10.1016/j.ebiom.2016.05.037
PMCID: PMC4972532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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