Article
Phenome-Genome Profiling of Single Bacterial Cell by Raman-Activated Gravity-Driven Encapsulation and Sequencing.
Small (Weinheim an der Bergstrasse, Germany) - 1 Jul 2020
Xu Teng, Gong Yanhai, Su Xiaolu, Zhu Pengfei, Dai Jing, Xu Jian, Ma Bo
Abstract excerpt
The small size and low DNA amount of bacterial cells have hindered establishing phenome-genome links in a precisely indexed, one-cell-per-reaction manner. Here, Raman-Activated Gravity-driven single-cell Encapsulation and Sequencing (RAGE-Seq) is presented, where individual cells are phenotypically screened via single-cell Raman spectra (SCRS) in an aquatic, vitality-preserving environment, then the cell with...
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