Article

Precision culturomics enabled by unlabeled single-cell morphology and Raman spectra

2025-06-29

Abstract excerpt

Selective enrichment of target bacteria from complex communities such as the human microbiome has remained a challenge. Here we report a solution based on morphology, Raman spectrometry and the Laser-Induced Forward Transfer technology, which works at microbial single cells, many generations before they appear as colonies. We develop a machine learning-based framework that enables species-level targeted sorting of...

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Literature Corpus work: 1c3da950-2fd6-58bd-837e-123a9198fade
DOI: 10.1101/2025.06.27.661433

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