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Article

Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD.

Molecular neurodegeneration - 8 Jun 2020

Tang Xiaoqiang, Toro Arturo, T G Sahana, Gao Junli, Chalk Jessica, Oskarsson Björn, Zhang Ke

Abstract excerpt

Ever since a GGGGCC hexanucleotide repeat expansion mutation in C9ORF72 was identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), three competing but nonexclusive hypotheses to explain how this mutation causes diseases have been proposed and are still under debate. Recent studies in the field have tried to understand how the repeat expansion...

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Identifiers

PMID: 32513219
DOI: 10.1186/s13024-020-00383-7
PMCID: PMC7282082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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