Article
A Stop-Gain Mutation within MLPH Is Responsible for the Lilac Dilution Observed in Jacob Sheep.
Genes - 4 Jun 2020
Posbergh Christian J, Staiger Elizabeth A, Huson Heather J
Abstract excerpt
A coat color dilution, called lilac, was observed within the Jacob sheep breed. This dilution results in sheep appearing gray, where black would normally occur. Pedigree analysis suggested an autosomal recessive inheritance. Whole-genome sequencing of a dilute case, a known carrier, and sixteen non-dilute sheep was used to identify the molecular variant responsible for the coat color change. Through investigation...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Codon, Nonsense
- Exons
- Hair Color
- Mutation
- Myosin Heavy Chains
- Myosin Type V
- Phenotype
- Pigmentation
- Sheep
- rab27 GTP-Binding Proteins