Article
A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs.
The Journal of heredity - 1 Jan 2007
Drögemüller Cord, Philipp Ute, Haase Bianca, Günzel-Apel Anne-Rose, Leeb Tosso
Abstract excerpt
Coat color dilution in several breeds of dog is characterized by a specific pigmentation phenotype and sometimes accompanied by hair loss and recurrent skin inflammation, the so-called color dilution alopecia or black hair follicular dysplasia. Coat color dilution (d) is inherited as a Mendelian autosomal recessive trait. In a previous study, MLPH polymorphisms showed perfect cosegregation with the dilute...
Topics
- Aging
- Alternative Splicing
- Animals
- Carrier Proteins
- DNA Mutational Analysis
- Dogs
- Exons
- Gene Expression Regulation, Developmental
- Hair Color
- Mutation
- Pigmentation
- Polymorphism, Single Nucleotide
- Reverse Transcriptase Polymerase Chain Reaction
- Species Specificity