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Article

A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat.

Genomics - 1 Dec 2006

Ishida Yasuko, David Victor A, Eizirik Eduardo, Schäffer Alejandro A, Neelam Beena A, Roelke Melody E, Hannah Steven S, O'Brien Stephen J, Menotti-Raymond Marilyn

Abstract excerpt

Three proteins have been described in humans and mice as being essential for even distribution, transport, and translocation of pigment granules, with defects in these molecules giving rise to lighter skin/coat color. The dilute phenotype in domestic cats affects both eumelanin and phaeomelanin pigment pathways; for example, black pigmentation combined with dilute appears gray and orange pigments appear cream....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16860533
DOI: 10.1016/j.ygeno.2006.06.006

Genes

MLPH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat.PMID 16860533Read ↗

A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs.Semantic proximity Read ↗

A novel MLPH variant in dogs with coat colour dilution.Semantic proximity Read ↗

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogsSemantic proximity Read ↗

A Third MLPH Variant Causing Coat Color Dilution in Dogs.Semantic proximity Read ↗

A frameshift mutation in the melanophilin gene causes the dilute coat colour in rabbit (Oryctolagus cuniculus) breeds.Semantic proximity Read ↗

A Stop-Gain Mutation within MLPH Is Responsible for the Lilac Dilution Observed in Jacob Sheep.Semantic proximity Read ↗

Chromosomal assignment of the canine melanophilin gene (MLPH): a candidate gene for coat color dilution in Pinschers.Semantic proximity Read ↗

Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melanophilin gene accountable for a distinctive coat color in Belgian Blue cattle.Semantic proximity Read ↗

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