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Article

A novel MLPH variant in dogs with coat colour dilution.

Animal genetics - 1 Feb 2018

Bauer A, Kehl A, Jagannathan V, Leeb T

Abstract excerpt

Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss-of-function variants in the melanophilin gene (MLPH) cause a recessively inherited form of coat colour dilution in many mammalian and avian species including the dog. MLPH corresponds to the D locus in many domestic animals, and recessive alleles at this locus are frequently denoted with d. In this study, we investigated...

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Identifiers

PMID: 29349785
DOI: 10.1111/age.12632

Genes

MLPH

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A novel MLPH variant in dogs with coat colour dilution.PMID 29349785Read ↗

A Third MLPH Variant Causing Coat Color Dilution in Dogs.Semantic proximity Read ↗

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogsSemantic proximity Read ↗

A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs.Semantic proximity Read ↗

A Stop-Gain Mutation within MLPH Is Responsible for the Lilac Dilution Observed in Jacob Sheep.Semantic proximity Read ↗

Chromosomal assignment of the canine melanophilin gene (MLPH): a candidate gene for coat color dilution in Pinschers.Semantic proximity Read ↗

A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat.Semantic proximity Read ↗

Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melanophilin gene accountable for a distinctive coat color in Belgian Blue cattle.Semantic proximity Read ↗

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