Myeloid neoplasms with germline predisposition: Practical considerations and complications in the search for new susceptibility loci.

Abstract excerpt

Genomic research in hematological malignancies has focused far more prominently on somatic mutations than on germline variants. Although increasing numbers of germline variants are being identified, a substantial proportion of familial myeloid malignancies have no causal allele pinpointed. Here we review the biological, technological, and clinical challenges that stand in the way of the goal of establishing,...

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