Article
Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B.
PloS one - 1 Jan 2020
Hayashi Hideki, Wang Ting, Tanaka Masayuki, Ogiwara Sanae, Okada Chisa, Ito Masatoshi, Fukunishi Nahoko, Iida Yumi, Nakamura Ayaka, Sasaki Ayumi, Amano Shunji, Yoshida Kazuhiro, Otomo Asako, Ohtsuka Masato, Hadano Shinji
Abstract excerpt
The autophagy-endolysosomal pathway is an evolutionally conserved degradation system that is tightly linked to a wide variety of physiological processes. Dysfunction of this system is associated with many pathological conditions such as cancer, inflammation and neurodegenerative diseases. Therefore, monitoring the cellular autophagy-endolysosomal activity is crucial for studies on the pathogenesis as well as...
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