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In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis

26 Aug 2011

Abstract excerpt

Autophagy is involved in the pathological process of motor neuron death in amyotrophic lateral sclerosis (ALS). We have generated a novel double transgenic (DTg) mouse line by mating a green fluorescent protein (GFP)-fused microtubule-associated protein 1 light chain 3 (LC3) transgenic (LC3-Tg) mouse and a G93A mutant human Cu/Zn superoxide dismutase (mSOD1) transgenic (mSOD1-Tg) mouse. In vivo imaging of...

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PMID: 21628996
DOI: 10.4161/auto.7.9.16012

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