Article

Tissue-specific endothelial cell heterogeneity in human type 2 diabetes

2025-12-03

Abstract excerpt

Transcriptomic heterogeneity of microvascular endothelial cells (MVEC) within subcutaneous adipose tissue (SAT) in preclinical models of obesity/type 2 diabetes mellitus (T2DM) is well-established. Here, we examined if such heterogeneity exists between two canonical insulin-target tissues, SAT and skeletal muscle (SkM). Characterisation of SAT and SkM MVEC from humans with T2DM demonstrated that SAT, but not SkM,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f322bd3-b8f5-518a-9675-c28f304e4924
DOI: 10.64898/2025.12.01.691646

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific endothelial cell heterogeneity in human type 2 diabetesDOI 10.64898/2025.12.01.691646Read

Defining the vascular niche of human adipose tissue across metabolic statesSemantic proximity Read

Characterisation of diabetes-associated adipose tissue dysfunction across the spectrum of body mass indexSemantic proximity Read

Loss of endothelial cell heterogeneity in arteries after obesogenic dietSemantic proximity Read

Proteome of human subcutaneous adipose tissue stromal vascular fraction cells versus mature adipocytes based on DIGE.Semantic proximity Read

Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin.Semantic proximity Read

The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues agingSemantic proximity Read

Adipose tissue endothelial cells: insights into their heterogeneity and functional diversitySemantic proximity Read

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular SenescenceSemantic proximity Read

Single-cell insights into maladaptive endothelial plasticity and therapeutic targets in diabetic vascular complications.Semantic proximity Read

Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery diseaseSemantic proximity Read

Uncovering the heterogeneity of pancreatic endothelial cells using integrative and comparative single cell gene expression analysisSemantic proximity Read

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic ResponseSemantic proximity Read